Liselle A Fernandes

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Monocytes play a crucial role in controlling malaria infection. To facilitate our research into the development of antibody-mediated immunity against pregnancy-associated malaria we have established several novel malaria-specific flow cytometric phagocytosis assays based on ethidium bromide staining of DNA present in blood stage trophozoites. The first(More)
BACKGROUND Recent studies suggest that infection with human T-lymphotropic virus 1 (HTLV-1) might be associated with bronchiectasis among Indigenous Australians. The present study compared the clinical characteristics and outcomes of bronchiectasis in this population, according to HTLV-1 serologic status. METHODS We performed a retrospective cohort study(More)
OBJECTIVE To compare infection-related mortality rates and pathogens isolated for Indigenous and non-Indigenous adult patients at Alice Springs Hospital (ASH). DESIGN, PARTICIPANTS AND SETTING Retrospective study of inhospital deaths of adults (patients aged > or = 15 years) associated with an infection during a medical or renal admission to ASH between 1(More)
OBJECTIVES We hypothesise that rising prevalence rates of non-communicable diseases (NCDs) increase infection risk and worsen outcomes among socially disadvantaged Indigenous Australians undergoing a rapid epidemiological transition. DESIGN Available pathology, imaging and discharge morbidity codes were retrospectively reviewed for a period of 5 years(More)
Human immunodeficiency virus type 1 (HIV-1) coinfection decreases antibodies to variant surface antigens implicated in pregnancy-associated malaria (VSA-PAM) caused by Plasmodium falciparum. The effect of HIV-1 on antibody functions that may protect mothers from pregnancy-associated malaria is unknown. Sera from multigravid pregnant women with malaria and(More)
Results One-hundred and twenty patients were admitted during the study period, HTLV-1 serology was performed for 92 (75.8%) patients. Western blots confirmed HTLV-1 infection in 52 (58.4%) cases and were indeterminate for 3 patients. HTLV-1 seropositive patients more often had bilateral bronchiectasis (HTLV-1+, 37/ 51; HTLV-1-, 18/36; p=0.032) and ground(More)
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