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BACKGROUND Major depression is highly recurrent. Antidepressant maintenance treatment has proven efficacy against recurrent depression. AIMS Comparison of prophylactic efficacy of citalopram versus placebo in unipolar, recurrent depression. METHODS Patients 18-65 years of age with recurrent unipolar major depression (DSM-IV), a Montgomery-Asberg(More)
BACKGROUND AND PURPOSE The aim of the study was to investigate the efficacy and safety of the selective serotonin reuptake inhibitor citalopram in treating poststroke depression, since available treatments are usually poorly tolerated. METHODS A 6-week double-blind, placebo-controlled trial was undertaken. Diagnosis and outcome were determined using the(More)
This study describes the development of post-stroke depression (PSD) prospectively during the first year post-stroke in 285 unselected stroke patients. An appropriate unselected population-based control group without cerebral pathology is included for comparison. Psychiatric assessment with the Hamilton Depression Rating Scale (HDRS) was undertaken(More)
The study is a validation study of two psychogeriatric depression rating scales, The Geriatric Depression Scale (GDS) and the Cornell Scale for Depression in Dementia (CSDD). The sensitivity and specificity, and the convergent and criterion validity of the two scales as well as the inter-rater reliability of the CSDD are reported. Two independent clinicians(More)
OBJECTIVE To examine whether late and very-late first-contact schizophrenia carry a risk for later development of dementia. METHODS By linkage of the psychiatric and the somatic nation-wide registers of all out- and in-patients with hospital contact in Denmark, we identified all patients with first ever contact during the period from January 1994 to(More)
BACKGROUND Associations between vitamin B-12 deficiency and impaired cognitive function and depression have been reported. METHODS A randomized placebo controlled study including 140 individuals with an increased plasma methylmalonic acid (0.40-2.00 micromol/l) not previously treated with vitamin B-12. Cognitive function was assessed by the Cambridge(More)
OBJECTIVE The aim of the study was to assess the external and internal validity of the 6- and 17-item versions of the Hamilton Rating Scale for Depression (HAM-D(6) and HAM-D(17)), the Bech-Rafaelsen Melancholia Scale, the 15- and 30-item versions of the Geriatric Depression Scale, and the Cornell Scale for Depression in Dementia in a population of(More)
In-patients with severe major depression were treated in the acute phase with electroconvulsive therapy (ECT) in combination with antidepressants. The drug treatment consisted of two randomized trials which were both extended into the post-ECT continuation phase. Patients with electrocardiological impairment were randomized to either 30 mg paroxetine daily(More)
An unselected cohort of 285 stroke patients, median age 69 years, were studied for correlation between potential risk factors and the 1-year incidence of post-stroke depression (PSD). The following factors correlated significantly with PSD: a history of previous stroke, a history of previous depression, female gender, living alone and social distress(More)
Background. Our T-PEMF trial has been revisited with focus on the pharmacopsychometric triangle in which effect size is used when comparing wanted versus unwanted clinical effects and quality of life as outcomes. In this analysis, we have especially focused on the self-reported HAM-D(6). Methods. The antidepressive medication which the patients were(More)