Lisa Saville Young

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Nontuberculous mycobacteria (NTM) are important environmental pathogens that can cause a broad spectrum of diseases. The last few years brought several changes in this expanding field: The number of infections that can be associated with specific species as well as the number of new species as etiological agents has exploded due to the development of new(More)
We previously proposed a "counting model" for meiotic crossover interference, in which double-strand breaks occur independently and a fixed number of noncrossovers occur between neighboring crossovers. Whereas in some organisms (group I) this simple model alone describes the crossover distribution, in other organisms (group II) an additional(More)
BACKGROUND Necrotizing fasciitis (NF) is an uncommon fulminant soft tissue infection characterized by extensive fascial necrosis. Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) isolates producing the Panton-Valentine leukocidin (PVL) cytotoxin have been associated with serious necrotizing infections, but NF caused by CA-MRSA has(More)
OBJECTIVE To determine the efficacy of combination drug therapy for disseminated Mycobacterium avium complex infection in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN Prospective, nonrandomized, before-after comparison. SETTING Outpatient clinics at three university medical centers. PATIENTS Seventeen patients with at least two(More)
OBJECTIVES To determine risk factors for acquisition of multidrug-resistant (MDR) Acinetobacter baumannii infection during an outbreak, to describe the clinical manifestations of infection, and to ascertain the cost of infection. DESIGN Case-control study. SETTING Surgical intensive care unit in a 400-bed urban teaching hospital and level 1 trauma(More)
Using small palindromes to monitor meiotic double-strand-break-repair (DSBr) events, we demonstrate that two distinct classes of crossovers occur during meiosis in wild-type yeast. We found that crossovers accompanying 5:3 segregation of a palindrome show no conventional (i.e., positive) interference, while crossovers with 6:2 or normal 4:4 segregation for(More)
The resurgence of tuberculosis has been documented in both developed and developing countries and is associated with the spread of human immunodeficiency virus (HIV) infection. In the USA, the steady decline in the incidence of tuberculosis witnessed during the past three decades has halted, and since early 1986, a resurgence of tuberculosis has been noted.(More)
A complex interaction of host and microbial factors is unquestionably related to the pathogenesis of gram-negative rod bacteremia in neutropenic, immunocompromised patients. In this paper we summarize evidence that colonization of the gastrointestinal tract often precedes systemic invasion by klebsiellae andPseudomonas aeruginosa, but that the factors(More)