Lisa S Ziemer

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High expression of circulating plasma vascular endothelial growth factor (VEGF) in patients with cancer is an indicator of poor treatment response. Similarly, hypoxia in tumors, as measured by oxygen needle electrodes, has been found to predict for tumor-treatment failure. These two predictors may be related because hypoxia is a potent stimulator of VEGF(More)
OBJECTIVE To determine prevalence of seizures after use of iohexol for myelography and identify associated risk factors in dogs. DESIGN Retrospective study. ANIMALS 182 dogs that received iohexol for myelography in 1998. PROCEDURE Medical records were reviewed for age, breed, sex, weight, dose and total volume of iohexol, injection site, number of(More)
In the present work, a novel method for detecting hypoxia in tumors, phosphorescence quenching, was used to evaluate tissue and tumor oxygenation. This technique is based on the concept that phosphorescence lifetime and intensity are inversely proportional to the oxygen concentration in the tissue sample. We used the phosphor Oxyphor G2 to evaluate the(More)
OBJECTIVE To assess risk factors for recurrence of clinical signs associated with thoracolumbar intervertebral disk disease (IVDD) in dogs that had decompressive laminectomy without attempted prophylactic treatment of other disk spaces. DESIGN Retrospective study. ANIMALS 229 dogs. PROCEDURE Medical records of dogs that had decompressive laminectomy(More)
Many factors affect the sensitivity and reliability of tumor vasculature assessment at the small doses of contrast agent necessary for imaging mice. In this study we investigate the dose-response relationship of ultrasound contrast agent for a minimal exposure power Doppler technique (minexPD) in a murine melanoma model. K1735 murine melanomas grown in 25(More)
OBJECTIVE To evaluate early medical and behavioral effects of deployment to the World Trade Center, Fresh Kills Landfill, or the Pentagon on responding search-and-rescue (SAR) dogs. DESIGN Prospective double cohort study. ANIMALS The first cohort included SAR dogs responding to the September 11, 2001, terrorist attacks (deployed), and the second cohort(More)
Mineral opacities within the tympanic bullae, termed otoliths, were detected in three dogs by means of radiography and computed tomography. Radiographic signs of otitis externa were present in two dogs. One dog had clinical signs of vestibular disease, whereas the other two dogs had no clinical evidence of ear disease. Otolithiasis may represent mineralized(More)
This study was aimed at determining if physiotherapy ultrasound (US) affected the fragile and leaky angiogenic blood vessels in a tumor. In 22 C3HV/HeN mice, a subcutaneous melanoma (K1735(22)) was insonated (1, 2 or 3 min) with continuous 1-MHz low-intensity (spatial-average temporal-average = 2.28 W cm(-2)), physiotherapy US. Contrast-enhanced (0.1 mL(More)
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