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Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key regulatory proteins. However, such cell culture studies involve synchronization using harsh methods, which may in(More)
Following an all-night fast, 45 patients with Parkinson's disease were examined using certain motor items present in the United Parkinson's Disease Rating Scale. All were given a single tablet of carbidopa 25 mg and levodopa 250 mg and re-examined 90 minutes later. In addition to this evaluation, 23 of these patients underwent further scoring over a 4-hour(More)
4-Hydroxyandrostenedione (4-OHA) was administered (250 mg intramuscularly 2-weekly) in a phase 2 clinical trial to 20 postmenopausal patients with advanced breast cancer, who had failed other endocrine therapy. Seven out of 18 assessable patients (39%) responded with minimal toxicity. Endocrine studies demonstrated that the drug produced significant initial(More)
a r t i c l e i n f o We present the first data on hawksbill turtle post-nesting migrations and behaviour in the Arabian region. Tracks from 90 post-nesting turtles (65 in the Gulf and 25 from Oman) revealed that hawksbills in the Arabian region may nest up to 6 times in a season with an average of 3 nests per turtle. Turtles from Qatar, Iran and the UAE(More)
a r t i c l e i n f o We present a previously unrecorded short-term behavioural response by hawksbill sea turtles to elevated sea surface temperatures in the Persian/Arabian Gulf. Surface waters typically exceed 30 °C for sustained periods during the summer, and can be likened to a natural living laboratory for understanding thermoregulatory behaviour by(More)
Analysis of circulating tumor DNA in plasma as diagnosis and during follow-up of lung cancer patients. Detecting of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Development of a membrane array-based multimarker assay for detection of circulating cancer cells in patients with non-small(More)
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