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The first step in fertilization is the interaction of the capacitated sperm with the zona pellucida. It has been proposed that the initial interaction, as in other types of cell adherence, is due to complementary interacting sites on the opposing surfaces of the gametes. This work intended to investigate the role of carbohydrates in sperm-egg binding in(More)
OBJECTIVE To assess the comparative contribution of endometrial and oocytic aging to the decline in fertility with age. DESIGN Retrospective analysis of conception and abortion rates in an egg donation program, with respect to donor and recipient ages. PATIENTS All oocyte recipients had ovarian failure. Donors were women undergoing in vitro(More)
Pregnant ICR mice were injected daily with 30 mg cyclosporin (CS)/kg body weight on days 6-8 or 10-12 of gestation. In parallel, control mice were administered saline injections on the same gestational days. The mice were sacrificed on days 12, 15, 17 or 19 of gestation. The number of resorption sites counted, the embryos and placentae were carefully(More)
The generation of active suppressor cells has been induced in vitro by preculturing of splenocytes from normal mice in the presence of mouse amniotic fluid (MAF) and alpha-fetoprotein (AFP). By using freshly explanted splenocytes, addition of such precultured lymphocytes abrogated the generation of specific cytotoxic lymphocytes (CTL) in primary mixed(More)
Recent evidence suggests that decidualization can be considered a modified inflammatory reaction. In this work we intended to determine whether the prostaglandin inhibitor diclofenac could affect implantation. Rat blastocysts were cultured in diclofenac in vitro, then implanted to host mothers on day 5 of pseudopregnancy. Large doses of diclofenac in(More)
Embryo transfer probably produces a lower incidence of implantation than the physiological incidence despite all other factors seeming similar. The only factor known to be present physiologically and absent in embryo transfer is the presence of sperm in the uterine cavity. Implantation and decidualization are often considered a modified form of inflammatory(More)
Daily plasma beta-HCG levels from days 11 to 18 after ovum retrieval (OR) were evaluated in a group of 73 women who became pregnant following in-vitro fertilization and embryo replacement (IVF-ER). The 47 patients who had a normal ongoing pregnancy could be distinguished from the 26 patients with a pathological pregnancy (pre-clinical abortion, clinical(More)