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  • Thomas S Griffith, Steven R. Wiley, Marek Z. Kubin, Lisa M. Sedger, Charles R. Maliszewski, Neil A. Fanger
  • Medicine
  • The Journal of experimental medicine
  • 1999 (First Publication: 19 April 1999)
  • TRAIL (tumor necrosis factor [TNF]-related apoptosis-inducing ligand) is a molecule that displays potent antitumor activity against selected targets. The results presented here demonstrate that humanContinue Reading
  • Mark J. Smyth, Erika Cretney, +5 authors Ko Okumura
  • Biology, Medicine
  • The Journal of experimental medicine
  • 2001 (First Publication: 19 March 2001)
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is expressed by in vitro activated natural killer (NK) cells, but the relevance of this observation to the biological function of NKContinue Reading
  • Lisa M. Sedger, Moira B. Glaccum, +8 authors Brian C. Gliniak
  • Biology, Medicine
  • European journal of immunology
  • 2002 (First Publication: 1 August 2002)
  • To define the normal physiological role for the TRAIL/Apo2L in vivo, we generated TRAIL/Apo2L gene-targeted mice. These mice develop normally and show no defects in lymphoid or myeloid cellContinue Reading
  • Michael J. Schreiber, Lisa M. Sedger, Grant Mcfadden
  • Biology, Medicine
  • Journal of virology
  • 1997 (First Publication: 1 March 1997)
  • The myxoma virus tumor necrosis factor (TNF) receptor homolog, M-T2, is expressed both as a secreted glycoprotein that inhibits the cytolytic activity of rabbit TNF-alpha and as an endoglycosidaseContinue Reading
  • Lisa M. Sedger, Sarah R. Osvath, +4 authors Grant Mcfadden
  • Medicine, Biology
  • Journal of virology
  • 2006 (First Publication: 15 September 2006)
  • The poxvirus tumor necrosis factor receptor (TNFR) homologue T2 has immunomodulatory properties; secreted myxoma virus T2 (M-T2) protein binds and inhibits rabbit TNF-alpha, while intracellular M-T2Continue Reading