Lisa M Wesoloski

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Mutation of the mouse Usp14 gene, encoding the homolog of yeast deubiquitinating enzyme Ubp6, causes ataxia. Here we show that deletion of the UBP6 gene in Saccharomyces cerevisiae causes sensitivity to a broad range of toxic compounds and antagonizes phenotypic expression and de novo induction of the yeast prion [PSI+], a functionally defective(More)
Most of the peptides presented by major histocompatibility complex (MHC) class I molecules require processing by proteasomes. Tripeptidyl peptidase II (TPPII), an aminopeptidase with endoproteolytic activity, may also have a role in antigen processing. Here, we analyzed the processing and presentation of the immunodominant human immunodeficiency virus(More)
Low temperature scanning tunneling microscopy studies revealed both monomer and dimer forms of decacyclene (DC) on atomically clean Cu(100) and Cu(111). The observed image contrast in DC is strongly bias dependent and also influenced by tip modifications. Alternatively, dimers appear solely as protrusions and are nearly bias independent. We provide evidence(More)
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