Lisa J. McQuay

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Assigning biological functions to uncharacterized proteins is a fundamental problem in the postgenomic era. The increasing availability of large amounts of data on protein-protein interactions (PPIs) has led to the emergence of a considerable number of computational methods for determining protein function in the context of a network. These algorithms,(More)
INTRODUCTION Epidemiological studies have linked domperidone use with serious cardiac arrhythmias, including sudden cardiac death, but data on age, dose, and duration of use are limited. OBJECTIVES The aim of this study was to assess the risk of out-of-hospital sudden cardiac death associated with domperidone use versus proton pump inhibitors (PPIs),(More)
We show here that the problem of maximizing a family of quantitative functions, encompassing both the modularity (Q-measure) and modularity density (D-measure), for community detection can be uniformly understood as a combinatoric optimization involving the trace of a matrix called modularity Laplacian. Instead of using traditional spectral relaxation, we(More)
STUDY OBJECTIVE To estimate the incidence and relative risk of a hospitalization or emergency visit for noninfectious liver injury in users of eight oral antimicrobials-amoxicillin, amoxicillin-clavulanic acid, clarithromycin, cefuroxime, doxycycline, levofloxacin, moxifloxacin, telithromycin-compared with nonusers of these antimicrobials. DESIGN(More)
BACKGROUND The ascertainment of sudden cardiac death (SCD) in electronic health databases is challenging. OBJECTIVES Our objective was to evaluate the applicability of the validated computer definition of SCD developed by Chung et al. in a retrospective study of SCD and domperidone exposure in the Clinical Practice Research Datalink (CPRD). METHODS We(More)
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