Lisa J. Graham

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Solid amorphous dispersions are frequently used to improve the solubility and, thus, the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Spray-drying, a well-characterized pharmaceutical unit operation, is ideally suited to producing solid amorphous dispersions due to its rapid drying kinetics. This paper describes a novel(More)
OBJECTIVE This study provides a longitudinal assessment of distress in longer-term oesophageal cancer carers, while examining illness perception schema as a possible determinant of change in distress over time. METHODS Oesophageal cancer carers (n = 171), 48 months post-diagnosis, were assessed at baseline and 12 months later with the Illness Perception(More)
Online monitoring of viable cell volume (VCV) is essential to the development, monitoring, and control of bioprocesses. The commercial availability of steam-sterilizable dielectricspectroscopy probes has enabled successful adoption of this technology as a key noninvasive method to measure VCV for cell-culture processes. Technological challenges still exist,(More)
Cell physiology dynamically affects the nutrient requirements of a culture. It is critical to obtain data over appropriate time intervals to assess the impact of process conditions on the cell population. By optimizing bioreactor operation, feed strategies and media composition , we can limit the number of experiments to obtain the empirical data sets. For(More)
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