Lisa J. Graham

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Solid amorphous dispersions are frequently used to improve the solubility and, thus, the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Spray-drying, a well-characterized pharmaceutical unit operation, is ideally suited to producing solid amorphous dispersions due to its rapid drying kinetics. This paper describes a novel(More)
Online monitoring of viable cell volume (VCV) is essential to the development, monitoring, and control of bioprocesses. The commercial availability of steam-sterilizable dielectricspectroscopy probes has enabled successful adoption of this technology as a key noninvasive method to measure VCV for cell-culture processes. Technological challenges still exist,(More)
Cell physiology dynamically affects the nutrient requirements of a culture. It is critical to obtain data over appropriate time intervals to assess the impact of process conditions on the cell population. By optimizing bioreactor operation, feed strategies and media composition , we can limit the number of experiments to obtain the empirical data sets. For(More)
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