Lisa Colledge

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Resolution of infection by Leishmania sp. is critically dependent on activation of CD4(+) T helper cells. Naive CD4(+) T helper cells are primed by dendritic cells which have responded to an activation signal in the periphery. However, the role of Leishmania-infected dendritic cells in the activation of an anti-Leishmania immune response has not been(More)
In a reply to Jerome K. Vanclay’s manuscript “Impact Factor: outdated artefact or stepping-stone to journal certification?” we discuss the value of journal metrics for the assessment of scientific-scholarly journals from a general bibliometric perspective, and from the point of view of creators of new journal metrics, journal editors and publishers. We(More)
Leishmania infection inhibits the capacity of macrophages (MPhi) to present antigens to CD4(+) T cells. Relocation of MHC class II and H-2DM to the parasitophorous vacuole (PV) and their subsequent degradation by the parasite may contribute to this defect. Dendritic cells (DC) are critical for initiation of primary T cell responses. DC can process(More)
MHC class II molecules present peptides, derived largely from exogenous antigens, to CD4+ T cells. Complex-generation occurs mainly in the specialized late endosomal MHC class II-rich compartment (MIIC) vesicles of antigen-presenting cells (APC). Dendritic cells (DC) have been reported to store intact antigen in MIIC until the receipt of an activation(More)
Project Snowball (www.projectsnowball.info) is a public service project that aims to help universities benchmark their performance across a broad range of research activities. The objectives of the project are to determine a standard set of common metrics and to share the methodology behind those metrics publically. With a set of common metrics defined by(More)
BACKGROUND Bisexual- and lesbian-identified women have significantly worse mental health than heterosexual women. Less evidence exists about mental health differences between lesbian and bisexual women. METHODS Self-completion survey with community-based, opportunistic sampling recruited 937 bisexual-identified and 4769 lesbian-identified women.(More)