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Inorganic sulfate (SO4) is an essential metabolite for the synthesis of sulfated mucopolysaccharides and steroid sulfates in the fetus and placenta. The authors' previous study of pregnant women at delivery revealed a substantial increase in serum SO4 compared with nonpregnant adults. To determine whether or not this difference was related to altered renal(More)
Controlled-flow ion chromatography has significantly improved the precision with which inorganic sulfate (SO4) can be measured in serum. In this study, we have shown that serum SO4 is increased in pregnancy. The increase appears to follow gestational age, resulting in a 39% higher value by the middle of the third trimester. We suggest that this increase is(More)
Inorganic sulfate is a cosubstrate for numerous sulfoconjugation reactions, including sulfation of estrogen steroids in the fetoplacental unit. It is known that the availability of inorganic sulfate can be the rate-limiting factor in these reactions, but fluxes of inorganic sulfate across the maternal-placental barrier have not been well characterized.(More)
We measured serum osteocalcin concentrations in 82 pregnant and 21 nonpregnant women. Osteocalcin values declined in the second trimester, but returned to nonpregnant levels late in the third trimester. The mean serum osteocalcin concentration in 36 women during pregnancy (mean gestation, 26 weeks) of 2.8 ng/mL was significantly lower than that in(More)
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