Lisa Adamiak

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The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used(More)
Complex signaling cascades, ubiquitous in living systems, inspire the pursuit of advanced materials that can amplify molecular-level interactions into multi-length scale signal transduction processes. N. C. Gianneschi, N. L. Abbott, and co-workers seek to combine stimuli-responsive polymers with liquid crystals (LC), which are ideally suited to dynamically(More)
Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator,(More)
Synthesis of biologically active peptide-polymer amphiphiles (PPAs), and characterization of assemblies formed by PPAs at the interfaces of liquid crystal (LC) microdroplets, is shown to permit the use of PPAs in strategies that can trigger ordering transitions in LC microdroplets in response to targeted biomolecular events.
Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a(More)
A study was conducted to survey the tolerance of ring-opening metathesis polymerization (ROMP) with respect to amino acid (a.a) identity of pentapeptide-modified norbornene-based monomers. A library of norbornyl-pentapeptides were prepared with the general structure, norbornyl-GX2PLX5, where residue 'X' was changed at each of the two positions (2 or 5)(More)
Cellular uptake by macrophages and ensuing clearance by the mononuclear phagocyte system stands as a significant biological barrier for nanoparticle therapeutics. While there is a growing body of work investigating the design principles essential for imparting nanomaterials with long-circulating characteristics and macrophage evasion, there is still a(More)
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