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The ordinary least squares estimation is based on minimization of the squared distance of the response variable to its conditional mean given the predictor variable. We extend this method by including in the criterion function the distance of the squared response variable to its second conditional moment. It is shown that this “second-order” least squares(More)
The paper presents the method of moments estimation for generalized linear measurement error models using the instrumental variable approach. The measurement error has a parametric distribution that is not necessarily normal, while the distributions of the unobserved covariates are nonparametric. We also propose simulation-based estimators for the situation(More)
A series of N-alkyl or aryl substituted isoindigo derivatives have been synthesized and their anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the target compounds exhibited significant antitumor activity, including compounds 6h and 6k (against K562 cells), 6i (against HeLa cells) and 6j (against A549 cells).(More)
The purpose of this study was to develop a reservoir-type transdermal delivery system for isosorbide dinitrate (ISDN). The developed patch consisted of five layers from bottom to top, namely, a temporary liner, an adhesive layer, a rate-controlling membrane, a reservoir and a backing. The effects of chemical penetration enhancers, reservoir materials and(More)
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is a highly conserved, sequence-specific RNA-binding protein that recruits translational repression or cytoplasmic polyadenylation machinery to target mRNAs. Recent studies have shown that CPEBs are expressed in somatic tissues and have essential functions supporting tumor growth,(More)
Wild-type p53-induced phosphatase 1 (Wip1) is a member of the protein phosphatase 2C family, which is characterized by distinctive oncogenic properties. Overexpression of Wip1 is observed in certain types of human tumors that are associated with significantly poor prognosis. This study aimed to detect the expression of Wip1 in gliomas and to analyze its(More)
A 100 J level XeCl laser pumped by an intense relativistic electron beam- FLASH II was constructed at Northwest Institute of Nuclear Technology. in China. FLASH II is a low impedance REB accelerator. It consists of a 64 stage Marx generator, pulse forming line, field-distortion main switch, pulse transmission line, output lineand diode. The cathode of diode(More)
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