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Scaffold proteins form a framework to organize signal transduction by binding multiple partners within a signaling pathway. This shapes the output of signal responses as well as providing specificity and localization. The Membrane Associated Guanylate Kinases (MAGuKs) are scaffold proteins at cellular junctions that localize cell surface receptors and link(More)
Tandem PDZ domains have been suggested to form structurally independent supramodules. However, dissimilarity between crystallography and NMR models emphasize their malleable conformation. Studies in full-length scaffold proteins are needed to examine the effect of tertiary interactions within their native context. Using single-molecule fluorescence to(More)
The phase behavior of a kind of pseudogemini surfactant in aqueous solutions, formed by the mixture of sodium dodecyl benzene sulfonate (SDBS) and butane-1,4-bis (methylimidazolium bromide) ([mim-C4-mim]Br2) or butane-1,4-bis(methylpyrrolidinium bromide) ([mpy-C4-mpy]Br2) in a molar ratio of 2 : 1, is reported in the present work. When [mim-C4-mim]Br2 or(More)
Novel gemini supra-amphiphiles, [Mim-4-Mim][DBS](2) and [Mim-4-Mim][DS](2), were facilely constructed. A slight variation of building blocks can effectively modulate the driving forces for the fabrication of gemini supra-amphiphiles, thus leading to the fine control of subsequent self-assemblies. [Mim-4-Mim][DS](2), constructed via electrostatic attraction,(More)
In the crystal structure of the title compound, C(9)H(14)N(4) (2+)·2Br(-), the cation and anions have crystallographic mirror symmetry, with the mirror plane running through the central CH(2) group for the cation. The latter are stacked along the a axis, forming channels hosting the bromide anions. The crystal packing is stabilized by C-H⋯Br(More)
It was found for the first time that rich lamellar structures are formed by a single-tailed amphiphilic ionic liquid (IL), 1-dodecyl-3-methylimidazolium β-naphthalene sulfonate ([C12mim][Nsa]), in aqueous solutions without any additives. With increasing IL concentration, spontaneous transition from micelles to unilamellar and multilamellar vesicles, planar(More)
Neuropathic pain is a chronic disease with hallmarks such as chronic allodynia and hyperalgesia. Previous studies have shown that the transforming growth factor-β superfamily acts as a protecting factor against neuropathic pain. In the current study, we found that growth and differentiation factor 10 (GDF10), which belongs to the transforming growth(More)
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