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To explore combinations of genetic markers and to estimate their joint action, decision trees are built on the basis of marker frequencies in both disease and control groups. Youden's index (0.1-0.9 for a single marker) is calculated for genetic markers with different diagnostic capacities. When 23 single genetic markers with diagnostic power 0.10 are… (More)
To explore combinations of genetic markers and to estimate their joint action, a new parameter, the Biomarker Index, is introduced as a measure of diagnostic power and compared with Youden’s Index and Relative Risk.