Lioubov Dombrovskaia

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The findings of epidemiological study of rotavirus infections among children in Gorki over the period of 1981-1985 are analyzed. The age of the patients is specified, as are the disease seasonal patterns and the incidence rates of its manifest and asymptomatic forms, and of carriership cases among healthy children in different foci of this infection.
A vast amount of bioinformatics information is continuously being introduced to different databases around the world. Handling the various applications used to study this information present a major data management and analysis challenge to researchers. The present work investigates the problem of integrating heterogeneous applications and databases towards(More)
Fuzzy based models have been used in many areas of research. One issue with these models is that rule bases have the potential for indiscriminant growth. Inference systems with large number of rules can be overspecified, have model comprehension issues and suffer from bad performance. In this research we investigate the use of a genetic algorithm towards(More)
This paper describes a neural network based inference system developed as part of a bioinformatic application in order to help implement a systematic search scheme for the identification of genes which encode enzymes of metabolic pathways. The inference system uses BLAST sequence alignment values as inputs and generates a classification of the best(More)
This paper describes the development of an inference system used for the identification of genes that encode enzymes of metabolic pathways. Input sequence alignment values are used to classify the best candidate genes for inclusion in a metabolic pathway map. The system workflow allows the user to provide feedback, which is stored in conjunction with(More)
The RT-PCR assay for the detection of all human enteroviruses was used to analyze fecal samples, cerebrospinal fluid (CSF), respiratory tract swabs, and sera from 204 patients with symptoms of viral infection. Enteroviruses were detected in 31.37% of cases. The proposed method analyzes every type of clinical samples. The relative detection rate of(More)
The materials on the epidemiological supervision of poliomyelitis in a large city, carried out in 1972-1981, are presented. Two periods differing in morbidity rate, in the level of population immunity to poliomyelitis and in the activity of the poliovirus circulation are defined. The supervision of poliomyelitis is shown to be capable of influencing the(More)
The authors carried out epidemiological examination of 160 foci of acute paretic diseases (APD) with serovirological examination of 181 patients and 413 contacts. Polioviruses were found to be etiologically responsible for the disease, as indicated by the results of serological examination in 37% of the patients, and by isolation of polioviruses (of the I(More)