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OBJECTIVE This study was performed to compare the efficacy and safety of tianeptine and paroxetine in the treatment of major depression. Anxiolytic drug use was systematically reported to provide an indirect evaluation of the anxiolytic activity of both treatments. Zopiclone use was assessed to provide an indirect evaluation of the possible hypnotic… (More)
As evaluation of patients functioning has become the key-stone of geriatric practice, the appropriated choice of a measuring instrument is of great importance. This article reviews rules and guidelines for a general approach to the orientation of this choice as well as the criteria of reliability of the chosen instrument. Starting from the principle that… (More)
DIAGNOSIS Recently published research has provided new elements for longstanding questions concerning depression in the elderly. The wide differences in epidemiological data are largely due to differences in the population studied and age-related changes in lifestyle. The relative proportions of syndromic and infra-syndromic states of depression appear to… (More)
Although the existence of chronic depression has been recognized for a long time, their definition was too inaccurate to enable reliable studies concerning their treatment. Among the numerous diagnostic classes that patients with chronic depression were assigned to, neurotic depression was the most common one, and was often considered to be unresponsive to… (More)
If some recent studies seem to reveal a more specific familial relationship for dysthymia in addition to a previously known familial relationship to mood disorders, and if results concerning the relationship between dysthymia and depressive personality as well as the search for possible biological and psychological correlates support the nosological… (More)
Interests and limitations of rating scales and diagnostic criteria are quite well figured by their psychometric qualities. Some of those qualities are described. What is being measured, the purpose of the instrument and the compatibility of those qualities are discussed. Some examples driven from clinical research are shown.
Dysthymia is the last diagnostic label introduced after a series of precursors to describe a disorder whose nosological status has long been dubious. The results of published epidemiological, as well as clinical studies about its presentation, course and outcome partly support the validity of this construct - although their interpretation is limited by… (More)