Lionel Prin

Didier Lefranc4
Sylvain Dubucquoi4
Patrick Vermersch3
Monique Capron2
4Didier Lefranc
4Sylvain Dubucquoi
3Patrick Vermersch
2Monique Capron
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To date, none of the myelin-associated Ag targets definitively discriminates between the immune response observed in multiple sclerosis (MS) patients and healthy subjects. However, it has been shown recently that analysis of global immune Ab profiles such as natural autoantibody reactivities can help to distinguish between normal individuals and patients(More)
  • Fanny Legrand, Aline Renneville, Elizabeth MacIntyre, Samuel Mastrilli, Felix Ackermann, Jean Michel Cayuela +19 others
  • 2013
Imatinib is the treatment of choice for FIP1L1/PDGFRA (F/P)-associated chronic eosinophilic leukemia (F/P + CEL), but its optimal dosing, duration, and possibility of discontinuation are still a matter of debate. A retrospective multicenter study was conducted with 44 F/P + CEL patients identified in the French Eosinophil Network and treated with imatinib.(More)
  • Virginie Dutoit-Lefèvre, Sylvain Dubucquoi, David Launay, Vincent Sobanski, Patricia Dussart, Philippe Chafey +6 others
  • 2015
Serological proteome analysis (SERPA) combines classical proteomic technology with effective separation of cellular protein extracts on two-dimensional gel electrophoresis, western blotting, and identification of the antigenic spot of interest by mass spectrometry. A critical point is related to the antigenic target characterization by mass spectrometry,(More)
  • Guillaume Lefèvre, Marie-Christine Copin, Delphine Staumont-Sallé, Martine Avenel-Audran, Hélène Aubert, Alain Taieb +22 others
  • 2014
The CD3-CD4+ aberrant T-cell phenotype is the most described in the lymphoid variant of hypereosinophilic syndrome (L-HES), a rare form of HES. Only a few cases have been reported, and data for these patients are scarce. To describe characteristics and outcome of CD3-CD4+ L-HES patients, we conducted a national multicentric retrospective study in the French(More)
Background. Absence of acquired protective immunity in endemic areas children leads to higher susceptibility to severe malaria. To investigate the involvement of regulatory process related to self-reactivity, we evaluated potent changes in auto-antibody reactivity profiles in children and older subjects living in malaria-endemic zones comparatively to(More)
This paper describes a comparative evaluation of two applications delivering a multimedia course: a conventional web server (WS) and an integrated e-learning platform in the form of a virtual campus (VC). We used a qualitative method for comparing their acceptance of the on-line course provided by the two different interfaces. The two groups were globally(More)
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