Lion Novak

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PURPOSE On past Childrens Cancer Group (CCG) trials, children with acute lymphoblastic leukemia and unfavorable presenting features had obtained an event-free survival (EFS) rate of no better than 50%. Following promising pilot experience, this study was conducted to determine the benefit and morbidity of two intensive experimental regimens, Reg A, based on(More)
Twenty children with acute lymphoblastic leukemia in second (18 patients) or third (two patients) complete remission after bone marrow relapse received allogeneic bone marrow transplants from histocompatible sibling donors. The preparative regimen for marrow transplantation consisted of 12 doses of 3,000 mg/m2 cytosine arabinoside twice daily for six days(More)
The incidence of transitional cell carcinoma (TCC), the fourth most common neoplasm diagnosed in men, is rising. Despite the development of several noninvasive diagnostic tests, none have gained full recognition by the clinicians. Gene expression profiling of tumors can identify new molecular markers for early diagnosis and disease follow-up. It also allows(More)
STUDY OBJECTIVE To determine the effects of cranial irradiation on neuropsychological test performance evident 9 months after diagnosis. DESIGN A companion study to a randomized clinical trial (CCG-105). SETTING Institutions participating in Childrens Cancer Group cooperative treatment trials. PATIENTS Seventy-four children aged 3.0 to 6.5 years with(More)
The changes of cells cultured in vitro after Calxyd effect which basical component is calcium hydroxide (Ca[OH]2) are described. The ingredient evoked cytoplasmic membrane changes, forming of pathological pseudopodies, the changes of nuclei and nucleoli. Fast start and development of pathological cell changes leading to their death in a short time and(More)