Linying Liu

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An enhanced understanding of the interactions between charged nanoparticles (CNPs) and a curved vesicle membrane may have important implications for the design of nanocarrier agents and drug delivery systems. In this work, coarse-grained molecular dynamics (CGMD) simulations of the CNPs with vesicles were performed to evaluate the effects of hydrophobicity,(More)
Electroporation is a common but efficient method for cell therapy. Pulses of duration ranging from microsecond to nanosecond with specific voltage have been studied in recent 20 years. Since electric field is also an important factor for effects on cell pore formation, we apply 100 ns and 10 ns pulses by varying their voltage acting on the complex cell(More)
Nanomedicine is widely developed in recent years. In nanomedicine system, nanoscale and nanostructured functional materials are used to manipulate the human biology systems at the molecular level for cancer imaging and therapy. New nanostructure based functional materials consist of nanoscale liposomes, spheres, micelles, capsules, emulsion, suspension and(More)
The effects of electric field on lipid membrane and cells have been extensively studied in the last decades. The phenomena of electroporation and electrofusion are of particular interest due to their wide use in cell biology and biotechnology. However, numerical studies on the electrofusion of cells (or vesicles) with different deformed shapes are still(More)
When cells are exposed to very short and high strength electric pulses, they will deform from spherical shape to ellipsoidal shape, and these effects may occur on cellular and organelles. Because of their potential clinical applications, selective effects on organelles are of particular interest. In this work, we use the finite element method to investigate(More)
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