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HLA class I polymorphism creates diversity in epitope specificity and T cell repertoire. We show that HLA polymorphism also controls the choice of Ag presentation pathway. A single amino acid polymorphism that distinguishes HLA-B*4402 (Asp116) from B*4405 (Tyr116) permits B*4405 to constitutively acquire peptides without any detectable incorporation into(More)
HLA-B*4402 and B*4403 are naturally occurring MHC class I alleles that are both found at a high frequency in all human populations, and yet they only differ by one residue on the alpha2 helix (B*4402 Asp156-->B*4403 Leu156). CTLs discriminate between HLA-B*4402 and B*4403, and these allotypes stimulate strong mutual allogeneic responses reflecting their(More)
BACKGROUND & AIMS Adrenal insufficiency (AI) has been reported in patients with advanced liver disease. Diagnosing AI is problematic owing to controversies in using total serum cortisol as a measure of adrenal function. No published data exist on directly measured plasma free cortisol (PFC) in patients with liver disease. METHODS This prospective study(More)
NY-ESO-1, a commonly expressed tumor antigen of the cancer-testis family, is expressed by a wide range of tumors but not found in normal adult somatic tissue, making it an ideal cancer vaccine candidate. Peptides derived from NY-ESO-1 have shown preclinical and clinical trial promise; however, biochemical features of these peptides have complicated their(More)
Our research focus has been on the development of discrete metal catalysts on carbon surfaces to achieve electrocatalytic oxidation of fuels such as methanol or reduction of CO2 or O2 to oxalate or water, respectively. Developing reproducible synthetic coupling strategies of discrete metal complexes to carbon surfaces is one step toward realizing(More)
The principle function of major histocompatibility complex (MHC) class I and II molecules is the presentation of peptide antigens to T lymphocytes of the immune system. These molecules are critical in shaping the Tcell repertoire in the thymus, the maintenance of peripheral tolerance and the initiation of effective immune responses against invading(More)
Since 2005 the Taiwanese government has invested over $1.2 billion into the M-Taiwan program to bolster Taiwan’s broadband mobile communications industry and infrastructure. In addition to building a fiber backbone and providing R&D grants for developing new technologies and novel applications, it has also co-funded the constructions of four(More)
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