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Pectin-based systems for colon-specific drug delivery via oral route.
Advantages, limitations, and possible future developments in pectin-based formulations with particular emphasis on the field of colon-specific drug delivery are discussed.
Pectin in controlled drug delivery – a review
Controlled drug delivery remains a research focus for public health to enhance patient compliance, drug efficiency and reduce the side effects of drugs. Pectin, an edible plant polysaccharide, has…
Development of polyion-complex hydrogels as an alternative approach for the production of bio-based polymers for food packaging applications: a review
Development of packaging materials from renewable resources has for a long time been desirable for sustainability reasons, but with recent explosion in prices of petroleum products, this now becomes…
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
- F. Yan, H. Cao, +7 authors D. Polk
- Medicine, BiologyThe Journal of clinical investigation
- 1 June 2011
P40 activation of EGFR was required for ameliorating colon epithelial cell apoptosis and chronic inflammation in oxazolone-induced colitis, and this data define what the authors believe to be a previously unrecognized mechanism of probiotic-derived soluble proteins in protecting the intestine from injury and inflammation.
Gelatin–pectin composite films from polyion-complex hydrogels
Preparation and properties of composite films from gelatin and low-methoxyl pectin from simultaneous reversible and permanent polyion-complex hydrogels are presented. Ionic interactions between…
Interaction of various pectin formulations with porcine colonic tissues.
Both P-N and P-94, by enhancing the protective barrier properties of mucus systems, may be useful alternatives for the treatment of mucUS related irritation and infection.
Preparation of poly(lactic acid) and pectin composite films intended for applications in antimicrobial packaging
- Linshu Liu, V. Finkenstadt, C. Liu, T. Jin, M. Fishman, K. B. Hicks
- Materials Science
- 15 October 2007
A pectin and poly(lactic acid) (PLA) composite was compounded by extrusion. A model antimicrobial polypeptide, nisin, was loaded into the composite by diffusion. The incorporation of pectin into PLA…
Antimicrobial activity of nisin incorporated in pectin and polylactic acid composite films against Listeria monocytogenes
Summary An extruded composite food packaging film containing pectin, polylactic acids (PLAs) and nisin was developed to inhibit Listeria monocytogenes. The mechanical properties and surface…
Composite films from pectin and fish skin gelatin or soybean flour protein.
- Linshu Liu, C. Liu, M. Fishman, K. B. Hicks
- Materials Science, MedicineJournal of agricultural and food chemistry
- 21 February 2007
The composite films were biodegradable and possessed moderate mechanical properties and a low water vapor transmission rate and are considered to have potential applications as packaging or coating materials for food or drug industries.
Pectin/Zein Beads for Potential Colon-Specific Drug Delivery: Synthesis and in Vitro Evaluation
- Linshu Liu, M. Fishman, K. B. Hicks, M. Kende, G. Ruthel
- Materials Science, MedicineDrug delivery
- 1 January 2006
In vitro study showed the capacity of the pectin/zein complex hydrogel beads to endure protease attack and residence time variation and the physical and biological properties of the new hydrogels were attributed to molecular entanglement of the two polymers.