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Stromal cells in the tumor microenvironment play a key role in the metastatic properties of a tumor. It is recognized that cancer-associated fibroblasts (CAFs) and endothelial cells secrete factors capable of influencing tumor cell migration into the blood or lymphatic vessels. We developed a microfluidic device that can be used to image the interactions(More)
Requirement prioritization is a process that allows selection of the “key” candidate requirements, the ones that are the most important for the construction of quality and cost-controlled software. Requirement prioritization brings certain issues and challenges related with the different stakeholders involved in the project, as well as with(More)
Almost all approaches to multiobjective optimization are based on Genetic Algorithms (GAs), and implementations based on Evolution Strategies (ESs) are very rare. Thus, it is crucial to investigate how ESs can be extended to multiobjective optimization, since they have, in the past, proven to be powerful single objective optimizers. In this paper, we(More)
The head shaking that results from robot locomotion is important because it difficults stable image acquisition and the possibility to rely on that information to act accordingly, for instance, to achieve visually-guided locomotion.
The global optimization of mixed integer non-linear problems (MINLP), constitutes a major area of research in many engineering applications. In this work, a comparison is made between an algorithm based on Simulated Annealing (M-SIMPSA) and two Evolutionary Algorithms: Genetic Algorithms (GAs) and Evolution Strategies (ESs). Results concerning the handling(More)