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BACKGROUND Distribution of body fat is more important than the amount of fat as a prognostic factor for life expectancy. Despite that, body mass index (BMI) still holds its status as the most used indicator of obesity in clinical work. METHODS We assessed the association of five different anthropometric measures with mortality in general and(More)
OBJECTIVE To estimate the high risk group for cardiovascular disease in a well defined Norwegian population according to European guidelines and the systematic coronary risk evaluation system. DESIGN Modelling study. SETTING Nord-Tröndelag health study 1995-7 (HUNT 2), Norway. PARTICIPANTS 5548 participants of the Nord-Tröndelag health study 1995-7,(More)
OBJECTIVE Our first objective is to describe total, age- and gender-specific prevalences of subjects in a well-defined population for whom medical follow-up is indicated due to unfavourably high blood pressure and/or cholesterol levels, as defined by the 2003 European guidelines on cardiovascular disease prevention in clinical practice. Our second objective(More)
RATIONALE, AIMS AND OBJECTIVES Clinicians are generally advised to consider several risk factors when evaluating patients' cardiovascular disease (CVD) risk. Our aim was to study whether combined assessment of five traditional risk factors might help doctors demarcate a relatively distinct and manageable group of high-risk individuals. We selected five(More)
BACKGROUND Previous studies indicate that clinical guidelines using combined risk evaluation for cardiovascular diseases (CVD) may overestimate risk. The aim of this study was to model and discuss implementation of the current (2007) hypertension guidelines in a general Norwegian population. METHODS Implementation of the current European Guidelines for(More)
RATIONALE, AIMS AND OBJECTIVES Many clinical guidelines for cardiovascular disease (CVD) prevention contain risk estimation charts/calculators. These have shown a tendency to overestimate risk, which indicates that there might be theoretical flaws in the algorithms. Total cholesterol is a frequently used variable in the risk estimates. Some studies indicate(More)
The emerging concept of systems medicine (or 'P4 medicine'-predictive, preventive, personalized and participatory) is at the vanguard of the post-genomic movement towards 'precision medicine'. It is the medical application of systems biology, the biological study of wholes. Of particular interest, P4 systems medicine is currently promised as a revolutionary(More)
BACKGROUND Multimorbidity receives increasing scientific attention. So does the detrimental health impact of adverse childhood experiences (ACE). Aetiological pathways from ACE to complex disease burdens are under investigation. In this context, the concept of allostatic overload is relevant, denoting the link between chronic detrimental stress, widespread(More)
with a diseased person in an adequate manner demands, consequently, the ability to accrue an understanding of this person ' s unique biographical and relational context, in other words, a historical, socio-cultural, and linguistic competence. This demand precludes predefi ned labelling of a person ' s ailment in general and of reports on complex malfunction(More)
AIMS To estimate the potential gain of national screening programmes for colorectal cancer (CRC) by stool occult blood testing in the Nordic countries, with comparative reference to the burden of other causes of premature death. METHODS Implementation of national screening programmes for CRC was modelled among people 55-74 years in accordance with the(More)