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Plasma metabolomic profile in nonalcoholic fatty liver disease.
TLDR
Plasma metabolomic analysis revealed marked changes in bile salts and in biochemicals related to glutathione in subjects with NAFLD and healthy controls from NASH, which can potentially be used to follow response to therapeutic interventions. Expand
Untargeted Metabolomic Profiling as an Evaluative Tool of Fenofibrate-Induced Toxicology in Fischer 344 Male Rats
TLDR
Several metabolites related to liver function, kidney function, cell damage, and cell proliferation were altered by fenofibrate-induced toxicity at this dose, suggesting the possibility of oxidative stress as a mechanism of nongenotoxic carcinogenesis. Expand
Metabolic perturbance in autism spectrum disorders: a metabolomics study.
TLDR
This study detected abnormal amino acid metabolism, increased oxidative stress, and altered gut microbiomes in ASD, and the relationship of altered gut microbial co-metabolism and the disrupted metabolisms requires further investigation. Expand
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites
TLDR
A whole-genome sequencing study of common, low-frequency and rare variants to associate genetic variations with blood metabolite levels using comprehensive metabolite profiling in 1,960 adults highlights the importance of heterozygous rare variants in determining abnormal blood metabolic phenotypes in adults. Expand
Metabolomic profiling in Selaginella lepidophylla at various hydration states provides new insights into the mechanistic basis of desiccation tolerance.
TLDR
Most lipids were produced constitutively, with the exception of choline phosphate, which was more abundant in dry states and likely plays a role in membrane hydration and stabilization, and several polyunsaturated fatty acids were more abundantin the hydrated states, suggesting that these compounds likely help maintain membrane fluidity during dehydration. Expand
Analysis of the adult human plasma metabolome.
TLDR
Age-associated changes were more pronounced than those related to differences in sex or race in the population group the authors studied, and those that were found to be statistically altered with age, sex orRace were found. Expand
L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.
TLDR
Elevations of the putative oncometabolite l-2HG in the most common subtype of kidney cancer are reported and a novel mechanism for the regulation of DNA 5hmC levels is described. Expand
3‐hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis
TLDR
The findings support involvement of excitotoxicity and oxidative stress in the pathogenesis of PD and offer new directions for recognizing disease‐specific biochemical indicators. Expand
A Sister Group Contrast Using Untargeted Global Metabolomic Analysis Delineates the Biochemical Regulation Underlying Desiccation Tolerance in Sporobolus stapfianus[C][W][OA]
TLDR
Comparison of the two species in the fully hydrated state revealed intrinsic differences between the two metabolomes, suggesting that S. stapfianus had higher concentrations of osmolytes, lower concentrations of metabolites associated with energy metabolism, andHigher concentrations of nitrogen metabolites, suggesting it is primed metabolically for dehydration stress. Expand
Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.
TLDR
Data suggest that the perturbation of bile acid homeostasis is an early event of DILI, and selected bile acids in the circulation could be potentially used as sensitive and early DILi preclinical biomarkers. Expand
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