Linh Duy Pham

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Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a comparable enzyme was created and tested in a conspecific host.(More)
The open/dynamic environment of Service-Oriented Computing requires middleware that can cope with services that are heterogeneous, and possibly unknown, unreliable or untrusted. Service-oriented middleware also needs to support both, ad-hoc and long-lived relationships between such services, and provide mechanisms for service coordination and cooperation.(More)
The measles virus (MV) is serologically monotypic. Life-long immunity is conferred by a single attack of measles or following vaccination with the MV vaccine. This is contrary to viruses such as influenza, which readily develop resistance to the immune system and recur. A better understanding of factors that restrain MV to one serotype may allow us to(More)
Service oriented computing (SOC) is a paradigm for building new software applications from existing loosely-coupled services. During service composition, services available to play different roles in a composition may have variations in their business-level protocols. These protocols may involve communication between two services in a point-to-point(More)
Sodium iodide symporter (NIS) reporter gene imaging is an excellent technology for noninvasive cell fate determination in living animals unless the NIS-transduced cells reside in perigastric organs such as the spleen, liver, diaphragm, omentum, pancreas, perigastric lymph nodes or perigastric tumor deposits. Here we report that orally administered barium(More)
INTRODUCTION Hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) during amiodarone therapy is a rare but potentially lethal adverse effect. We report a case of severe hyponatremia associated with amiodarone, and discuss its clinical implications. CASE REPORT An 84-year-old Caucasian man with a past medical(More)
In a service composition, it is necessary to ensure that the behaviour of a constituent service is consistent with the requirements of the composition. In an adaptive service composition those behavioural requirements may be continually changing. This paper shows how the behavioural requirements in abstract service definitions (roles) can be dynamically and(More)
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