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Magnetic resonance imaging of melanoma exosomes in lymph nodes.

• Lingzhi Hu, Samuel A. Wickline, J. L. Linsley Hood
• Magnetic resonance in medicine
• 2015

PURPOSE Exosomes are cell derived extracellular nanovesicles that relay molecular signals pertinent to both normal physiologic and disease processes. The ability to modify and track exosomes in vivo… (More)

Programmable nanoparticle functionalization for in vivo targeting.

• Hua Pan, Jacob W Myerson, +10 authors Samuel A. Wickline
• FASEB journal : official publication of the…
• 2013

The emerging demand for programmable functionalization of existing base nanocarriers necessitates development of an efficient approach for cargo loading that avoids nanoparticle redesign for each… (More)

Antithrombin nanoparticles improve kidney reperfusion and protect kidney function after ischemia-reperfusion injury.

• Junjie Chen, Chandu Vemuri, +6 authors Samuel A. Wickline
• American journal of physiology. Renal physiology
• 2015

In the extension phase of acute kidney injury, microvascular thrombosis, inflammation, vasoconstriction, and vascular endothelial cell dysfunction promote progressive damage to renal parenchyma after… (More)

Bioimpedance spectroscopy for the estimation of body fluid volumes in mice.

• Michael E. Chapman, Lingzhi Hu, Craig F. Plato, Donald E Kohan
• American journal of physiology. Renal physiology
• 2010

Conventional indicator dilution techniques for measuring body fluid volume are laborious, expensive, and highly invasive. Bioimpedance spectroscopy (BIS) may be a useful alternative due to being… (More)

A generalized strategy for designing (19)F/(1)H dual-frequency MRI coil for small animal imaging at 4.7 Tesla.

• Lingzhi Hu, Frank D Hockett, +4 authors Samuel A. Wickline
• Journal of magnetic resonance imaging : JMRI
• 2011

PURPOSE To propose and test a universal strategy for building (19) F/(1) H dual-frequency RF coil that permits multiple coil geometries. MATERIALS AND METHODS The feasibility to design (19) F/(1) H… (More)

Assessing intrarenal nonperfusion and vascular leakage in acute kidney injury with multinuclear (1) H/(19) F MRI and perfluorocarbon nanoparticles.

• Lingzhi Hu, Junjie Chen, +7 authors Samuel A. Wickline
• Magnetic resonance in medicine
• 2014

PURPOSE We sought to develop a unique sensor-reporter approach for functional kidney imaging that employs circulating perfluorocarbon nanoparticles and multinuclear (1) H/(19) F MRI. METHODS (19) F… (More)

Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence.

• Lingzhi Hu, Junjie Chen, Xiaoxia Yang, Shelton D. Caruthers, Gregory M. Lanza, Samuel A. Wickline
• Magnetic resonance in medicine
• 2013

We present a novel blood flow-enhanced-saturation-recovery (BESR) sequence, which allows rapid in vivo T1 measurement of blood for both (1)H and (19)F nuclei. BESR sequence is achieved by combining… (More)

Diffusional mechanisms augment the fluorine MR relaxation in paramagnetic perfluorocarbon nanoparticles that provides a "relaxation switch" for detecting cellular endosomal activation.

• Lingzhi Hu, Lei Zhang, Junjie Chen, Gregory M. Lanza, Samuel A. Wickline
• Journal of magnetic resonance imaging : JMRI
• 2011

PURPOSE To develop a physical model for the (19)F relaxation enhancement in paramagnetic perfluorocarbon nanoparticles (PFC NP) and demonstrate its application in monitoring cellular endosomal… (More)

Evaluating Endothelial Damage in Acute Kidney Injury with Perfluorocarbon ( PFC ) Nanoparticles ( NP ) and 19 F MRI

• Lingzhi Hu, Junjie Chen, Xiaoxia Yang, Shelton D. Caruthers, Gregory M. Lanza, Samuel A. Wickline
• 2011

Figure 2. (a1-4) Representative MR and fluorescence images of injured kidneys: 1) BOLD T2* map; 2) F intensity map; 3) PFC NP fluorescence image at medulla; and 4) FITC-Lectin fluorescence image at… (More)

Clonality of multiple uterine leiomyomas.

• Shufang Wang, Qin Su, Shaojun Zhu, Jie Liu, Lingzhi Hu, Donghong Li
• Zhonghua bing li xue za zhi = Chinese journal of…
• 2002

OBJECTIVE To study the clonality of uterine leiomyomas, especially the relationship between different nodules in multinodular cases. METHODS Genomic DNA was extracted from fresh tissue samples and… (More)

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