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  • Lingyun Lai, Xiuyan Feng, +5 authors Hui Cai
  • Medicine, Chemistry
  • Pflügers Archiv - European Journal of Physiology
  • 2011 (First Publication: 1 March 2012)
  • WNK is a serine/threonine kinase. Mutation in WNK1 or WNK4 kinase results in pseudohypoaldosteronism type II (PHA II) featuring hypertension, hyperkalemia and metabolic acidosis. Sodium chlorideContinue Reading
  • Lingyun Lai, Jing Nan Chen, Chuan-ming Hao, Shanyan Lin, Yong Gu
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2006 (First Publication: 1 September 2006)
  • Accumulating evidence demonstrates that aldosterone can cause extra-cellular matrix (ECM) accumulation, in addition to regulating sodium and potassium homeostasis. Increased extra-cellular matrixContinue Reading
  • Lingyun Lai, Ai Pen, +5 authors Shanyan Lin
  • Biology, Medicine
  • Life sciences
  • 2007 (First Publication: 1 July 2007)
  • Accumulating evidence shows that aldosterone plays an important role in the pathogenesis of renal fibrosis but its mechanism has not been completely defined. Recently, exogenous administration ofContinue Reading
  • Jing Qian, Jianyong Zhong, +4 authors Lingyun Lai
  • Biology, Medicine
  • Discovery medicine
  • 2018 (First Publication: 1 December 2018)
  • To determine whether -344T/C CYP11B2 promoter polymorphism affects serum aldosterone levels and whether this polymorphism is an indicator of eGFR decline in patients with chronic kidney disease. -344Continue Reading