Lingshu Yin

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PURPOSE To compare the extent of tumor motion between 4-dimensional CT (4DCT) and cine-MRI in patients with hepatic tumors treated with radiation therapy. METHODS AND MATERIALS Patients with liver tumors who underwent 4DCT and 2-dimensional biplanar cine-MRI scans during simulation were retrospectively reviewed to determine the extent of target motion in(More)
PURPOSE The purpose of this work is threefold: (1) to explore biological consequences of the multileaf collimator (MLC) calibration errors in intensity modulated radiotherapy (IMRT) of prostate and head and neck cancers, (2) to determine levels of planning target volume (PTV) and normal tissue under- or overdose flagged with clinically used QA action(More)
In electron and proton radiotherapy, applications of patient-specific electron bolus or proton compensators during radiation treatments are often necessary to accommodate patient body surface irregularities, tissue inhomogeneity, and variations in PTV depths to achieve desired dose distributions. Emerging 3D printing technologies provide alternative(More)
PURPOSE To assess the impact of attenuation and scatter corrections on the calculation of single photon emission computed tomography (SPECT)-weighted mean dose (SWMD) and functional volume segmentation as applied to radiation therapy treatment planning for lung cancer. METHODS AND MATERIALS Nine patients with lung cancer underwent a SPECT lung perfusion(More)
The use of functional imaging in radiotherapy treatment (RT) planning requires accurate co-registration of functional imaging scans to CT scans. We evaluated six methods of image registration for use in SPECT-guided radiotherapy treatment planning. Methods varied in complexity from 3D affine transform based on control points to diffeomorphic demons and(More)
With traditional photon therapy to treat large postoperative pancreatic target volume, it often leads to poor tolerance of the therapy delivered and may contribute to interrupted treatment course. This study was performed to evaluate the potential advantage of using passive-scattering (PS) and modulated-scanning (MS) proton therapy (PT) to reduce normal(More)
BACKGROUND Intensity modulated arc therapy (IMAT) has been widely adopted for Stereotactic Body Radiotherapy (SBRT) for lung cancer. While treatment dose is optimized and calculated on a static Computed Tomography (CT) image, the effect of the interplay between the target and linac multi-leaf collimator (MLC) motion is not well described and may result in(More)
PURPOSE An adaptive proton therapy workflow using cone beam computed tomography (CBCT) is proposed. It consists of an online evaluation of a fast range-corrected dose distribution based on a virtual CT (vCT) scan. This can be followed by more accurate offline dose recalculation on the vCT scan, which can trigger a rescan CT (rCT) for replanning. METHODS(More)
Lingshu Yin; Lisa Tang; Ghassan Hamarneh; Vitali Moiseenko; Anna Celler; Sergey Shcherbinin; Tsien-Fei Fua; Anna Thompson; Mitchell Liu; Cheryl Duzenli; Brad Gill; Finbar Sheehan; John Powe; Daniel Worsley; (1) Physics and Astronomy, University of British Columbia (2) Medical Physics, Vancouver Cancer Centre, BC Cancer Agency (3) Computing Science, Simon(More)
We evaluated six methods for CT­CT registration for SPECT­guided radiotherapy treatment planning: affine registration with manual marking of corresponding control points either on the skin or interior to the lung, automatic rigid registration and three deformable registration methods (B­Spline, Demons and Level set). According(More)