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In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile(More)
Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction of BMPR2 signaling. The best response was achieved with FK506(More)
—This brief presents a reconfigurable VLSI architecture which is designed for multi-transform codec in several video coding standards of MPEG-2/4, VC-1, H.264/AVC and AVS. The reconfigurable multiple constant multiplication algorithm with two fusing strategies is provided to generate constant multipliers in the matrix calculation blocks. Additionally,(More)
RATIONALE S100A4/Mts1 is implicated in motility of human pulmonary artery smooth muscle cells (hPASMCs), through an interaction with the RAGE (receptor for advanced glycation end products). OBJECTIVE We hypothesized that S100A4/Mts1-mediated hPASMC motility might be enhanced by loss of function of bone morphogenetic protein (BMP) receptor (BMPR)II,(More)
The kidney is a highly specialized organ with a complex, stereotyped architecture and a great diversity of functions and cell types. Because the microscopic organization of the nephron, the functional unit of the kidney, has a consistent relationship to the macroscopic anatomy of the kidney, knowledge of the characteristic patterns of gene expression in(More)
— Partially reconfigurable systems are promising computing platforms for streaming applications, which demand both hardware efficiency and reconfigurable flexibility. To realize the full potential of these systems, a streaming-based partially reconfigurable architecture and unified software/hardware mul-tithreaded programming model (SPREAD) is presented in(More)
Deriving a circuit for a Boolean function or improving an available circuit are typical tasks solved by logic synthesis. Numerous algorithms in this area have been proposed and implemented over the last 50 years. This paper presents a "lazy" approach to logic synthesis based on the following observations: (a) optimal or near-optimal circuits for many(More)