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Ruthenium(ii) complexes with dppz: from molecular photoswitch to biological applications.
The latest results of Ru-dppz complexes that bind with DNA are introduced and the recent advances in biological applications of the Ru- dppz system in DNA binders, cellular imaging, anticancer drugs, protein aggregation detection and chemosensors are reviewed.
A mitochondrial targeted two-photon iridium(III) phosphorescent probe for selective detection of hypochlorite in live cells and in vivo.
Azo-Based Iridium(III) Complexes as Multicolor Phosphorescent Probes to Detect Hypoxia in 3D Multicellular Tumor Spheroids
This study reported the design and synthesis of a series of “off-on” phosphorescence probes for hypoxia detection in adherent and three-dimensional multicellular spheroid models that display a high selectivity for the detection of Hypoxia in 2D cells and 3D multICEllular spheroids.
A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors.
Ir4 is the first metal complex-based theranostic agent which can generate carbon radicals for oxygen-independent two-photon photodynamic therapy and the efficacy of Ir4 as a PDT agent was demonstrated under hypoxic conditions in vivo.
A fast and selective two-photon phosphorescent probe for the imaging of nitric oxide in mitochondria.
Iridium(III) Anthraquinone Complexes as Two-Photon Phosphorescence Probes for Mitochondria Imaging and Tracking under Hypoxia.
These probes possessed excellent specificity for mitochondria, which allowed imaging and tracking of the mitochondrial morphological changes in a hypoxic environment over a long period of time, and can visualize hypoxic mitochondria in 3D multicellular spheroids and living zebrafish through two-photon phosphorescence imaging.
Ruthenium(II) Complexes with Dppz: From Molecular Photoswitch to Biological Applications
Recent advances in hypoxic tumor detection
This review highlights some recent progress in the design, synthesis and application of fluorescent probes for hypoxia in solid tumors.