Lingjie Gu

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Background Adenoviral (Ad) vectors have been used for a variety of vaccine applications. Traditionally, Ad-based vaccines are designed to express antigens through transgene expression. However, in some cases these conventional Ad-based vaccines have had sub-optimal clinical results. These sub-optimal results are attributed in part to preexisting Ad serotype(More)
We previously reported that the xanthine nucleotide binding Goa mutant, GoaX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11a and G16a and characterized their nucleotide binding and receptor interaction. First, we found that G11aX and G16aX expressed in COS-7 cells bound xanthine 5*-O-(thiotriphosphate) instead of(More)
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