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  • Haruyuki Takemura, V Ashutosh Rao, +5 authors Yves Pommier
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2006 (First Publication: 13 October 2006)
  • The Mre11.Rad50.Nbs1 (MRN) complex binds DNA double strand breaks to repair DNA and activate checkpoints. We report MRN deficiency in three of seven colon carcinoma cell lines of the NCI AnticancerContinue Reading
  • Eileen Brantley, Smitha Antony, +5 authors Yves Pommier
  • Medicine, Biology
  • Cancer Chemotherapy and Pharmacology
  • 2005 (First Publication: 1 July 2006)
  • Purpose: The fluorinated benzothiazole analogue 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) exhibits selective and potent anticancer activity, and its lysylamide prodrugContinue Reading
  • Si-meng Chen, Chen-liang Guo, Jian Ding, Linghua Meng
  • Medicine
  • 2013 (First Publication: 15 April 2013)
  • Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Mammalian target of rapamycin (mTOR) has been validated as a promising target for cancer therapy. Several mTOR kinaseContinue Reading