Ling Zhai

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Post-translational histone modifications play important roles in regulating gene expression programs, which in turn determine cell fate and lineage commitment during development. One such modification is histone ubiquitination, which primarily targets histone H2A and H2B. Although ubiquitination of H2A and H2B has been generally linked to gene silencing and(More)
Accumulating evidences indicate that bisphenol A (BPA) exposure during early development increases the risk of obesity and insulin resistance in later life. Despite growing public concern, it is not totally clear about the mechanism of BPA. This study aimed to evaluate the effect of perinatal exposure to BPA on body weight, glucose metabolism and adipokine(More)
Posttranslational histone modifications play important roles in regulating chromatin structure and function (Martin and Zhang, Nat Rev Mol Cell Biol 6:838-849, 2005; Jenuwein and Allis, Science 293:1074-1080, 2001). One example of such modifications is histone ubiquitination, which occurs predominately on H2A and H2B. Recent studies have highlighted(More)
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