Ling Yang

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P-glycoprotein (P-gp), a drug efflux pump, affects the bioavailability of therapeutic drugs and plays a potentially important role in clinical drug-drug interactions. Classification of candidate drugs as substrates or inhibitors of the carrier protein is of crucial importance in drug development. Accurate classification is difficult to achieve due to two(More)
P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding cytotoxic agents out of cells, resulting in an obstacle in chemotherapeutic treatment of cancer. In order to aid in the development of potential P-gp inhibitors, we constructed a quantitative structure-activity relationship (QSAR) model of(More)
Systems pharmacology is an emerging field that integrates systems biology and pharmacology to advance the process of drug discovery, development and the understanding of therapeutic mechanisms. The aim of the present work is to highlight the role that the systems pharmacology plays across the traditional herbal medicines discipline, which is exemplified by(More)
The goal of engineering process control (EPC) is to minimize variability by adjusting some manipulative process variables. The goal of statistical process control (SPC) is to reduce variability by monitoring and eliminating assignable causes of variation. As suggested by Box and Kramer and others, it is possible to reduce both special cause and common cause(More)
A computational investigation has been carried out on CYP2A6 and its naphthalene inhibitors to explore the crucial molecular features contributing to binding specificity. The molecular bioactive orientations were obtained by docking (FlexX) these compounds into the active site of the enzyme. And the density functional theory method was further used to(More)