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Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1-infected individuals, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of initial CD4 receptor binding. These(More)
During HIV-1 infection, antibodies are generated against the region of the viral gp120 envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these antibodies, VRC01 achieves broad neutralization of diverse viral strains. We determined the crystal structure of VRC01 in complex with a human immunodeficiency virus HIV-1 gp120 core. VRC01(More)
Arabidopsis thaliana seedlings undergo photomorphogenesis in the light and etiolation in the dark. Long Hypocotyl in Far-Red 1 (HFR1), a basic helix-loop-helix transcription factor, is required for both phytochrome A-mediated far-red and cryptochrome 1-mediated blue light signaling. Here, we report that HFR1 is a short-lived protein in darkness and is(More)
Containment of highly lethal Ebola virus outbreaks poses a serious public health challenge. Although an experimental vaccine has successfully protected non-human primates against disease, more than six months was required to complete the immunizations, making it impractical to limit an acute epidemic. Here, we report the development of accelerated(More)
We present a novel and simple experimental method called physical human interactive guidance to study human-planned grasping. Instead of studying how the human uses his/her own biological hand or how a human teleoperates a robot hand in a grasping task, the method involves a human interacting physically with a robot arm and hand, carefully moving and(More)
In this paper, a new corner detector is proposed based on evolution difference of scale pace, which can well reflect the change of the domination feature between the evolved curves. In Gaussian scale space we use Difference of Gaussian (DoG) to represent these scale evolution differences of planar curves and the response function of the corners is defined(More)
An efficient and novel technique is developed for detecting and localizing corners of planar curves. This paper discusses the gradient feature distribution of planar curves and constructs gradient correlation matrices (GCMs) over the region of support (ROS) of these planar curves. It is shown that the eigen-structure and determinant of the GCMs encode the(More)
Recommender systems have been successfully used to address the problem of information overload, where consumers of goods and services have too many choices and overwhelming amount of information about each choice. Here we focus on service recommendation and demonstrate the need for using multiple criteria regarding service qualities, and the need to(More)
Water is essential for all living organisms. Aquaporin proteins are the major facilitator of water transport activity through cell membranes of plants including soybean. These proteins are diverse in plants and belong to a large major intrinsic (MIP) protein family. In higher plants, MIPs are classified into five subfamilies including plasma membrane(More)