Ling Tu

Dao Wen Wang4
Xiaosai Fang3
4Dao Wen Wang
3Xiaosai Fang
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OBJECTIVE Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play crucial and diverse roles in cardiovascular homeostasis. The anti-inflammatory, antihypertensive, and pro-proliferative effects of EETs suggest a possible beneficial role for EETs on insulin(More)
Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs) which play important roles in various pathophysiological processes. Interestingly, CYP-derived eicosanoids are vasodilatory, at least in part through their ability to activate eNOS and subsequent NO release. This study(More)
BACKGROUND Cell senescence is central to a large body of age related pathology, and accordingly, cardiomyocytes senescence is involved in many age related cardiovascular diseases. In consideration of that, delaying cardiomyocytes senescence is of great importance to control clinical cardiovascular diseases. Previous study indicated that bradykinin (BK)(More)
A modified quadratic partial least squares (MQPLS) algorithm based on non-linear constrained programming is proposed, in which a sequential unconstrained minimisation technique is employed to calculate the outer input weights and the parameters of inner relationship. Other existing quadratic partial least squares (QPLS) algorithms are also reviewed and(More)
BACKGROUND We previously demonstrated oxymatrine, an alkaloid from the Chinese medicine radix Sophorae flavescentis, ameliorates hemodynamic disturbances and cardiac fibrosis; however, the underlying mechanisms are unclear. Here, we investigated the effect and mechanism of action of oxymatrine on aldosterone-induced cardiac fibroblast to myofibroblast(More)
BACKGROUND Scientific workers play an important role in the development of science and technology. However, evidence is lacking with regard to the associations between their dietary factors and their health-related quality of life (HRQOL). METHODS A cross-sectional survey was conducted among 775 scientific workers from multiple universities and institutes(More)
Correction We deeply regret that we have inadvertently made a minor mistake in our publication [1] and we feel it necessary to correct this error. Following publication of our work, we reviewed all the Western blots of the experiments; all showed an identical trend in terms of scientific interpretation. Unfortunately, it was subsequently noticed that Figure(More)
OBJECTIVE To investigate the mechanism of intense noise-induced apoptosis of vestibular hair cells in guinea pigs and the effect of phosphorylated c-Jun N-terminal kinase (JNK) signal transduction pathway in intense noise-induced apoptosis of vestibular hair cells. METHODS Thirty-two guinea pigs were randomly and equally divided into 1, 5, and 15 d(More)
Previous studies have shown that acute systemic administration of ethanol-induced striatal ascorbic acid (AA) release in mice and rats. In the present study, in vivo brain microdialysis coupled with high performance liquid chromatography (HPLC) with electrochemical detection (ECD) was used to comparatively evaluate the effects of clozapine on(More)
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