Enhanced Production of a Novel Cyclic Hexapeptide Antibiotic (NW-G01) by Streptomyces alboflavus 313 Using Response Surface Methodology
- Zhengyan Guo, Ling Shen, Z. Ji, Wenjun Wu
- Biology, MedicineInternational Journal of Molecular Sciences
- 24 April 2012
A system for optimizing medium components in order to enhance NW-G01 production had a 2.73-fold increase and a prediction model has been built in the experiments of central composite design and response surface methodology, and its validation has been further verified.
NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities
- Zhengyan Guo, Ling Shen, Z. Ji, Jiwen Zhang, Luzhi Huang, Wenjun Wu
- Medicine, BiologyJournal of antibiotics (Tokyo. )
- 6 March 2009
NW-G01, a novel cyclic hexadepsipeptide antibiotic, exhibited strong antibacterial activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, methicillin-resistant S. aUREus and their MIC values were 3.90, 3.81 and 7.81 μg ml−1, respectively.
NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation
- Zhengyan Guo, Z. Ji, Wenjun Wu
- ChemistryJournal of antibiotics (Tokyo. )
- 1 December 2010
NW-G01 is a novel cyclic hexapeptide antibiotic produced by Streptomyces alboflavus 313. Its relative structure was established by HR-ESI-MS, IR, 1D and 2D NMR techniques, the absolute structure was…
NW-G03, a related cyclic hexapeptide compound of NW-G01, produced by Streptomyces alboflavus 313
- Zhengyan Guo, Ling Shen, Wenjun Wu
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 26 October 2011
NW-G03, a related cyclic hexapeptide compound of NW-G01, produced by Streptomyces alboflavus 313
NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation
- Zhengyan Guo, Z. Ji, Wenjun Wu
- ChemistryJournal of antibiotics (Tokyo. )
- 12 October 2010
NW-G01 (I) is isolated as new antibiotic from the fermentation broth of Streptomyces alboflavus.
Isolation Methods of the Actinomycetes Under Extreme Environment
- Ling Shen, Zhengyan Guo, Wenjun Wu
- Engineering
- 2005
This article systematically introduced in this article that the separating methods most in use of the rare actinomycetes under the extreme environment in recent 10 years.
NW‐G03, a Related Cyclic Hexapeptide Compound of NW‐G01, Produced by Streptomyces alboflavus 313
- Zhengyan Guo, Ling Shen, Wenjun Wu
- Chemistry, Biology
- 3 April 2012
The objective of this research is to establish a theory of isolation, structure elucidation, physico-chemical properties and in vitro biological activity of Na6(CO3)(SO4)– Na2SO4 in response to the presence of Na2CO3 in the nucleus.