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Aquaporin-4 (AQP4), a predominant water channel of the brain, mediates transmembrane water movement at the blood-brain barrier and brain-cerebrospinal fluid interface. A broad pattern of evidence indicates that AQP4 and regulators of its expression are potential targets for treatment of brain swelling, but whether it participates in the regulation of(More)
The final common pathway in the demise of dopaminergic neurons in Parkinson's disease may involve oxidative stress and excitotoxicity. In this study, we examined the neuroprotective effects of a novel ATP-sensitive potassium channel (K(ATP)) opener, iptakalim (IPT), against H(2)O(2)-induced cytotoxicity in rat dopaminergic PC12 cells. Pretreatment with IPT(More)
OBJECTIVE To evaluate the risk factors for chronic obstructive pulmonary disease (COPD) in Xinjiang rural areas. METHODS This was a population-based and cross-sectional survey on prevalence of COPD in Xinjiang from December 2007 to December 2010. The cluster random sampling method was performed to collect the data from 3575 people in rural areas in(More)
High polymorphism is one of the most important features of human leukocyte antigen (HLA) alleles, which were initially classified by serotyping but have recently been re-grouped into supertypes according to their peptide presentation properties. Two relatively prevalent HLA alleles HLA-A*6801 and HLA-A*6802, are classified into the same serotype HLA-A68.(More)
Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardiovascular diseases as well as genome wide association studies were successful in indentifying the loci associated with this prominent life-threatening disease but still a substantial amount of casualty remains unexplained. Over the last decade, the(More)
To achieve secure communication in heterogeneous cryptography systems, we present a heterogeneous hybrid signcryption scheme. The proposed scheme allows a sender in an identity-based cryptography system to send multi-message to multi-receiver in a certificateless cryptography system with different master keys. At the same time, all users are mapped to a(More)
Cardiomyopathy is a heterogeneous heart disease. Although morbidity of pediatric cardiomyopathy has been on the increase, effective treatments have not been identified. The aim of the study was to examine the expression of ACR1 gene products in association with cardiomyopathy in children. In total, 73 patients and 76 healthy subjects were enrolled in the(More)
Heart disease-related deaths are the highest in most societies and congenital heart diseases account for approximately 40% of prenatal deaths and over 20% of mortality in the first few months after birth. Congenital heart disease affects approximately 1% of all newborns and is the causative factor for more deaths within the first year of life as compared to(More)
Cardiac failures in young children have shown an enormous trudge in recent past. The reason being medical community has laid more stress on cardiac insufficiency management on adult patients and has conducted a large amount of research on the management of heart failure in adults, which has given rise to significant changes in management in the last decade.(More)
Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying cause of fibrotic heart disease. There are(More)