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Decentralized Peer to Peer (P2P) networks offer both opportunities and threats. Its open and decentralized nature makes it extremely susceptible to malicious users spreading harmful content like viruses, trojans or, even just wasting valuable resources of the network. In order to minimize such threats, the use of community-based reputations as trust(More)
Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling pathways required to maintain quiescence are unknown. Using a transgenic Notch reporter mouse and quantitative reverse-transcription polymerase chain reaction analysis of Notch(More)
Data perturbation techniques are one of the most popular models for privacy preserving data mining (Agrawal and Srikant, 2000; Aggarwal and Yu, 2004). It is especially convenient for applications where the data owners need to export/publish the privacy-sensitive data. A data perturbation procedure can be simply described as follows. Before the data owner(More)
Among the key properties that distinguish adult mammalian stem cells from their more differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged periods of time. However, the molecular pathways for the maintenance of stem-cell quiescence remain elusive. Here we use adult mouse muscle stem cells (satellite cells) as a(More)
Accurate cellular localization is crucial for the effective function of most signalling molecules and nuclear translocation is central to the function of transcription factors. The passage of large molecules between the cytoplasm and nucleus is restricted, and this restriction affords a mechanism to regulate transcription by controlling the access of(More)
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by binding of hedgehog proteins to the multipass Patched-1 (PTCH) receptor, which in the absence of hedgehog suppresses the activity of the seven-pass membrane protein Smoothened(More)
The ability to maintain quiescence is critical for the long-term maintenance of a functional stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem cells and how they change with age remain largely unknown. In this study, we explore the chromatin features of adult skeletal muscle stem cells, or satellite cells (SCs),(More)
Distributed in-memory key-value stores such as memcached have become a critical middleware application within current web infrastructure. However, typical x86based systems yield limited performance scalability and high power consumption as their architecture with its optimization for single thread performance is not wellmatched towards the memory-intensive(More)
The presence of tangles of abnormally phosphorylated tau is a characteristic of Alzheimer's disease (AD), and the loss of synapses correlates with the degree of dementia. In addition, the overexpression of interleukin-1 (IL-1) has been implicated in tangle formation in AD. As a direct test of the requirement for IL-1 in tau phosphorylation and synaptophysin(More)