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Human neuronal models of hereditary spastic paraplegias (HSP) that recapitulate disease-specific axonal pathology hold the key to understanding why certain axons degenerate in patients and to developing therapies. SPG4, the most common form of HSP, is caused by autosomal dominant mutations in the SPAST gene, which encodes the microtubule-severing ATPase(More)
Gold nanoparticles-poly(luminol) (Plu-AuNPs) hybrid film and multi-walled carbon nanotubes with incorporated β-cyclodextrin modified glassy carbon electrode (β-CD-MWCNTs/Plu-AuNPs/GCE) was successfully prepared for simultaneous determination of dopamine (DA) and uric acid (UA). The surface of the modified electrode has been characterized by X-ray(More)
I investigate the different roles played by two components of trading volume, informed-trading and liquidity-trading, in the volatility-volume relation at the aggregate level. Using transaction data and an extended trading model of Easley, Kiefer, O’Hara and Paperman (1996), I estimate a marketwide private information arrival rate (PIAR) variable and use it(More)
Here, a stepwise procedure for efficiently generating telencephalic glutamatergic neurons from human pluripotent stem cells (PSCs) has been described. The differentiation process is initiated by breaking the human PSCs into clumps which round up to form aggregates when the cells are placed in a suspension culture. The aggregates are then grown in hESC(More)
Vimentin is a newly recognized target for corneal fibrosis. Using primary rabbit corneal fibroblasts and myofibroblasts we show that myofibroblasts, unlike fibroblasts, display impaired cell spreading and cell polarization, which is associated with increased levels of soluble serine-38 phosphorylated vimentin (pSer38Vim). This pSer38Vim isoform is(More)
Large, slow moving landslides in the Berkeley Hills cause costly damage and pose a potential threat to public safety due to the close proximity of the Hayward Fault. Now in the Berkeley Hills there are four large, slow moving, deep-seated landslides. All the landslides extend through residential areas and move on the order of cm/year, each covering an area(More)
The persistent scatterers (PS) technique is a powerful remote sensing technology that exploits a long series of synthetic aperture radar data for monitoring ground deformations with millimeter accuracy on a high spatial density of ground targets. One of the major limitations of this technique is due to atmospheric effects, and in particular to high Water(More)