Ling-Jen Chen

Publications16
h-index7
Citations112
Highly Influential Citations3
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Disposition and Metabolism of Cumene in F344 Rats and B6C3F1 Mice
TLDR
The absorption, distribution, metabolism, and excretion of [14C]cumene (isopropylbenzene) was studied in male rats and mice of both sexes after oral or intravenous administration and the highest tissue 14C levels in rats were observed in adipose tissue, liver, and kidney with no accumulation observed after repeat dosing up to 7 days. Expand
DISPOSITION OF 3-CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5 H )-FURANONE (MX) IN B6C3F1 MICE AND F344 RATS
TLDR
MX disposition appears to be dominated by its chemical reactivity with highest concentrations of radioactivity being found at the site of administration, with high, prolonged levels ofRadioactivity in blood compared to oral dosing. Expand
Hydrogen Splittings of Bis-Bicyclic Hydrazine Radical Cations
Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.
TLDR
The presence of an internal nucleophile in furosemide may have a significant effect on the toxicology and possibly the pharmacology of this furan. Expand
Metabolism of furans in vitro: ipomeanine and 4-ipomeanol.
TLDR
The complex structures of the reaction products of the enedial with biological nucleophiles may explain why the many attempts to identify 4-IPO adducts to protein have not been successful. Expand
Intermolecular Electron-Transfer Reactions Involving Hydrazines
The self-exchange electron-transfer (ET) rate constant k22 for 1,2,3,4,5-pentamethylferrocene was determined by NMR line broadening to be 8.5(±0.8) × 106 M-1 s-1 (25 °C, CD3CN/0.09 M Et4NBF4) and k11… Expand
In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids
Structural Information from Hydrazine Radical Cation Optical Absorption Spectra.
TLDR
Transition energies of the nitrogen-centered pi,pi absorption of tetraalkylhydrazine radical cations are quite sensitive to twist at the NN bond, nitrogen pyramidality, and mixing of the sigma orbitals with the pi system, so changes in E(op) caused by changes in pyramidality and sigma,pi interaction are predicted well by the calculations. Expand
9-(Diisopropylamino)-9-azabicyclo[3.3.1]nonane and Tetraisopropylhydrazine: Isolable Radical Cations from Hydrazines with Nearly Perpendicular Lone Pairs
Slow Electron Transfer Reactions Involving Tetraisopropylhydrazine
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