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Dynamics of the Southern Hemisphere Spiral Jet
Abstract The formation of the Southern Hemisphere spiral jet is investigated using observations over a 40-yr period. It is found that between late March and early April, the upper-troposphericExpand
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Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast
Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation.Expand
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Glucosidase-beta variations and Lewy body disorders.
It has been proposed that there is an increased frequency of glucosidase-beta mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of glucosidase-betaExpand
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Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations.
BACKGROUND Alpha-synuclein is involved in dopaminergic neurotransmission and has been implicated in a number of neurodegenerative disorders, such as Parkinson's disease. Recent studies, in humans andExpand
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Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast
DNA polymerases (Pols) ε and δ perform the bulk of yeast leading- and lagging-strand DNA synthesis. Both Pols possess intrinsic proofreading exonucleases that edit errors during polymerization. RareExpand
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dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants
Significance An increased rate of mutation, or “mutator phenotype,” generates genetic diversity that can accelerate cancer progression or confer resistance to chemotherapy drugs. New therapeuticExpand
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Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer detection by enabling the identification of mutant cancer molecules in minimally invasive body fluid samples. WeExpand
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Antimutator variants of DNA polymerases
Evolution balances DNA replication speed and accuracy to optimize replicative fitness and genetic stability. There is no selective pressure to improve DNA replication fidelity beyond the backgroundExpand
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Direct Quantification of in vivo Mutagenesis and Carcinogenesis Using Duplex Sequencing
The ability to accurately measure mutations is critical for basic research and identification of potential drug and chemical carcinogens. Current methods for in vivo quantification of mutagenesis areExpand
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