Lindsey M. Ouellette

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Escherichia coli O157:H7, a toxin-producing food and waterborne bacterial pathogen, has been linked to large outbreaks of gastrointestinal illness for more than two decades. E. coli O157 causes a wide range of clinical illness that varies by outbreak, although factors that contribute to variation in disease severity are poorly understood. Several recent(More)
Global patterns of gene expression of Escherichia coli K-12 during growth transitions have been deeply investigated, however, comparable studies of E. coli O157:H7 have not been explored, particularly with respect to factors regulating virulence genes and genomic islands specific to this pathogen. To examine the impact of growth phase on the dynamics of the(More)
The Escherichia coli O157 : H7 TW14359 strain was implicated in a multi-state outbreak in North America in 2006, which resulted in high rates of severe disease. Similarly, the O157 : H7 RIMD0509952 (Sakai) strain caused the largest O157 : H7 outbreak to date. Both strains were shown to represent divergent phylogenetic lineages. Here we compared global gene(More)
BACKGROUND Enterohemorrhagic Escherichia coli (EHEC) O157:H7, a food and waterborne pathogen, can be classified into nine phylogenetically distinct lineages, as determined by single nucleotide polymorphism genotyping. One lineage (clade 8) was found to be associated with hemolytic uremic syndrome (HUS), which can lead to kidney failure and death in some(More)
Escherichia albertii has been associated with diarrhea in humans but not with disease or infection in animals. However, in December 2004, E. albertii was found, by biochemical and genetic methods, to be the probable cause of death for redpoll finches (Carduelis flammea) in Alaska. Subsequent investigation found this organism in dead and subclinically(More)
STUDY DESIGN Clonal typing of neurogenic clones. OBJECTIVE To determine whether neurogenic clones carried over weeks in the urine of asymptomatic children with neurogenic bladder were similar to known uropathogenic clones associated with disease. SETTING Michigan State University; VA Medical Center, Minneapolis, MN, USA. METHODS Escherichia coli(More)
In order to provide a portable and accurate typing system for the unambiguous characterization of pathogenic Escherichia coli isolates to the scientific community, we have constructed an online database for multilocus sequence typing of pathogenic E. coli (EcMLST) using current Internet and open source technology. The system consists of an XML specification(More)
The genetic diversity of group B Streptococcus in young, nonpregnant women is not well studied. Application of multilocus sequence analysis to 85 group B Streptococcus strains recovered from college students revealed similarities and differences in distribution of group B Streptococcus lineages, compared with that of previously studied pregnant populations,(More)