Lindsey K. Tuominen

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BACKGROUND BAHD acyltransferases are involved in the synthesis and elaboration of a wide variety of secondary metabolites. Previous research has shown that characterized proteins from this family fall broadly into five major clades and contain two conserved protein motifs. Here, we aimed to expand the understanding of BAHD acyltransferase diversity in(More)
MOTIVATION The pre-estimate of the proportion of null hypotheses (π(0)) plays a critical role in controlling false discovery rate (FDR) in multiple hypothesis testing. However, hidden complex dependence structures of many genomics datasets distort the distribution of p-values, rendering existing π(0) estimators less effective. RESULTS From the basic(More)
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