Lindsey C Carlson

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OBJECTIVES To explore spatial variability within the cervix and the sensitivity of shear wave speed (SWS) to assess softness/stiffness differences in ripened (softened) vs unripened tissue. METHODS We obtained SWS estimates from hysterectomy specimens (n = 22), a subset of which were ripened (n = 13). Multiple measurements were made longitudinally along(More)
The cervix softens and shortens as its collagen microstructure rearranges in preparation for birth, but premature change may lead to premature birth. The global preterm birth rate has not decreased despite decades of research, likely because cervical microstructure is poorly understood. Our group has developed a multilevel approach to evaluating the human(More)
Although cervical softening is critical in pregnancy, there currently is no objective method for assessing the softness of the cervix. Shear wave speed (SWS) estimation is a noninvasive tool used to measure tissue mechanical properties such as stiffness. The goal of this study was to determine the spatial variability and assess the ability of SWS to(More)
OBJECTIVE To explore the feasibility of using shear wave speed (SWS) estimates to detect differences in cervical softening pre- and post-ripening in women undergoing induction of labor. METHODS Subjects at 37-41 weeks' gestation undergoing cervical ripening before induction of labor were recruited (n = 20). Examinations, performed prior to administration(More)
The uterine cervix softens, shortens, and dilates throughout pregnancy in response to progressive disorganization of its layered collagen microstructure. This process is an essential part of normal pregnancy, but premature changes are associated with preterm birth. Clinically, there are no reliable noninvasive methods to objectively measure cervical(More)
PURPOSE The generalized spectrum (GS) has been used to quantify nonrandomness of scattering sources and to characterize breast and liver tissues. In this work, we implement a multitaper GS approach creating parametric images of GS features that describe the degree of nonrandom structure in breast lesions. METHODS This IRB-approved, HIPAA compliant study(More)
The annual International Symposium on Ultrasonic Imaging and Tissue Characterization has long been recognized as one of the world’s leading forums concerned with ultrasonic technology for medical applications. Sixty-eight technical contributions were presented this year, our most ever. Many of the presentations dealt with clinical evaluation of novel(More)
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