Lindsay M. Johnson

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The mechanisms whereby fatty acids (FA) potentiate glucose-induced insulin secretion from the pancreatic beta cell are incompletely understood. In this study, the effects of palmitate on insulin secretion were investigated in isolated rat islets. Palmitate did not initiate insulin secretion at nonstimulatory glucose concentrations, but markedly stimulated(More)
investigation of the genetic control of the structure of a specific protein likely to be influenced by the method of selecting the mutants used for study. If the protein has enzymatic activity and use is made of the lack of enzymatic activity in mutants for identification and selection, there will doubtless be many alterations of the protein which pass(More)
Androdioecious Caenorhabditis have a high frequency of self-compatible hermaphrodites and a low frequency of males. The effects of mutations on male fitness are of interest for two reasons. First, when males are rare, selection on male-specific mutations is less efficient than in hermaphrodites. Second, males may present a larger mutational target than(More)
15 Androdioecious Caenorhabditis have a high frequency of self-compatible hermaphrodites and a 16 low frequency of males. The effects of mutations on male fitness are of interest for two reasons. 17 First, when males are rare, selection on male-specific mutations is less efficient than in 18 hermaphrodites. Second, males may present a larger mutational(More)
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