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Experimental rats were trained on multiple 2-odor discrimination tasks, whereas controls were given repeated sessions on Task 1 and then were tested on a novel 2-odor task. Experimental rats showed strong positive transfer across problems and approached errorless or near-errorless learning. Control rats maintained near-perfect performance on Task 1 but(More)
By using principlism to teach ethics, we are reinforcing a sense of professional superiority among health care professionals. If we are to adequately serve not just the disabled, but all those who come to us for care, we need to rethink and restructure ethics teaching to create a learning environment that promotes and enhances caring.
In this study we describe the occurrence of a calmodulin-like protein in normal human biological fluids. Extraction of the calmodulin-like protein from breast milk, saliva, serum and urine provided an extract with enhanced calmodulin immunoreactivity which, in the case of milk and saliva, showed a protein band comigrating with authentic calmodulin (Mr(More)
The prevalence of serum LATS and LATS-P in untreated Graves' disease has been studied in eighty-three patients with thyroid overactivity; twelve (14%) were found to have significant levels of LATs and LATS-P whilst fifty-nine (72%) had significant levels of LATS-P alone. Twelve (14%) had neither activity. There was a very wide range in both activities. LATS(More)
A series of unstimulated and stimulated saliva samples from healthy volunteers was tested for EGF by radioimmunoassay. Salivary EGF, like other salivary constituents, was secreted in a diurnal pattern. On stimulation the rate of EGF secretion doubled but the concentration fell by 70% because of dilution by salivary fluid. EGF secretion was positively(More)
OBJECTIVES Bipolar disorder (BD) is a debilitating illness, the psychopathology of which is associated with aberrant structural and functional differences in the brain. Despite the many advances in psychiatric research, our understanding of the complex neurobiological underpinnings of BD remains incomplete. The aim of this review was to critically examine(More)
BACKGROUND Emotion labeling deficits have been posited as an endophenotype for bipolar disorder (BD) as they have been observed in both patients and their first-degree relatives. It remains unclear whether these deficits exist secondary to the development of psychiatric symptoms or whether they can be attributed to risk for psychopathology. To explore this,(More)
Children of parents diagnosed with bipolar disorder are at greater risk for developing a variety of psychiatric disorders, however, the reasons remain unknown. The present study aimed to investigate gray matter integrity in high-risk bipolar offspring (HRO) and healthy offspring (HCO) using cortical thickness techniques. Here we examined healthy control(More)
Introduction: Quality assessment of included studies is an important component of systematic reviews. Objective: The authors investigated inter-rater and testeretest reliability for quality assessments conducted by inexperienced student raters. Design: Student raters received a training session on quality assessment using the Jadad Scale for randomised(More)
INTRODUCTION Depression is the leading cause of disability worldwide, affecting approximately 350 million people. Evidence indicates that only 60-70% of persons with major depressive disorder who tolerate antidepressants respond to first-line drug treatment; the remainder become treatment resistant. Electroconvulsive therapy (ECT) is considered an effective(More)