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Journals and Conferences
CONTEXT Substantial resources are being devoted to identify candidate genes for complex mental and behavioral disorders through inclusion of environmental exposures following the report of an interaction between the serotonin transporter linked polymorphic region (5-HTTLPR) and stressful life events on an increased risk of major depression. OBJECTIVE To… (More)
We review the literature on the familial resemblance of body mass index (BMI) and other adiposity measures and find strikingly convergent results for a variety of relationships. Results from twin studies suggest that genetic factors explain 50 to 90% of the variance in BMI. Family studies generally report estimates of parent-offspring and sibling… (More)
OBJECTIVE The authors seek to clarify, from both an epidemiologic and genetic perspective, the major risk factors for bulimia nervosa and to understand the relationship between narrowly defined bulimia and bulimia-like syndromes. METHOD Personal structured psychiatric interviews were conducted with 2,163 female twins from a population-based register.… (More)
OBJECTIVE To elucidate the nature of the etiologic relationship between personality and major depression in women. DESIGN A longitudinal twin design in which twins completed a time 1 questionnaire and, 15 months later, were personally interviewed for the occurrence of major depression during the last year and completed a time 2-questionnaire. Both… (More)
Data gathered in Australia and England on the social attitudes of spouses and twins are largely consistent with a genetic model for family resemblance in social attitudes. There is substantial assortative mating and little evidence of vertical cultural inheritance.
Bivariate twin analysis can determine the extent to which two disorders share common genetic, familial environmental, or individual-specific environmental risk factors. We applied this method to lifetime diagnoses of major depression and generalized anxiety disorder as assessed at personal interview in a population-based sample of 1033 pairs of female… (More)
BACKGROUND Very little is known about how different sets of risk factors interact to influence risk for psychiatric disorder. OBJECTIVE To replicate a recent report of a genotype-environment interaction that predicts risk for antisocial behavior in boys. DESIGN Characterizing risk for conduct disorder in boys in association with monoamine oxidase A… (More)
SummaryA model is developed to specify the environmental effect of one sibling on another for a polygenic trait. Such effects are detectable in principle and the approach is illustrated with twin data relating to psychoticism. The relationship between the model and those employed in the treatment of kin selection is indicated.
Little is known about the contribution of genetic and environmental factors to risk for juvenile psychopathology. The Virginia Twin Study of Adolescent Behavioral Development allows these contributions to be estimated. A population-based, unselected sample of 1412 Caucasian twin pairs aged 8-16 years was ascertained through Virginia schools. Assessment of… (More)
Measures of four dimensions of personality (Psychoticism, Extraversion, Neuroticism, and Lie scores) and six aspects of social attitudes (to sex, taxation, militarism, politics, religion and a general conservatism scale) were obtained by mailed questionnaire from 29,691 US subjects including adult twins (n = 14,761) their parents (n = 2360), their spouses… (More)